Wash your hands before and after use. Salicylic acid helps your skin absorb the sodium thiosulfate. In addition, sodium thiosulfate acts as a reducing agent or antioxidant, which neutralizes free radicals. However, it scavenges less oxygen than sodium sulfite. Shake well and apply a thin layer of lotion to cover the affected skin and surrounding area. Sodium thiosulfate has many roles including being used as an antidote to cyanide poisoning as well as an antifungal drug. It is typically found in its pentahydrate form which is either white in colour, or colourless altogether. Reply 4 Cyanide Poisoning, Heavy Metals, Liver Poisoning Posted by Ted (Bangkok, Thailand) on 09/16/2007 383 posts If you have an allergy to sodium thiosulfate or any other part of sodium thiosulfate. Calciphylaxis is a relatively rare condition characterized by ischemic skin lesions resulting from calcium deposits occluding microvessels creating painful areas of ecchymoses that lead to dark . It is used as a cleansing agent. Salicylic acid helps your skin absorb the sodium thiosulfate. What happens when you mix sodium thiosulfate and water? It is used as a preservative to prevent dried fruit from discoloring, and for preserving meats, and is used in the same way as sodium thiosulfate to convert elemental halogens to their respective hydrohalic acids, in photography and for reducing chlorine levels in pools. People also report that it trims the waistline and improves sleep and dream recall! Common interactions include dry skin among females. Sodium thiosulphate is a non-toxic chemical but can cause slight irritation on exposure to skin and eyes. LC50: Not available. Section 3: Hazards Identification Potential Acute Health Effects: Hazardous in case of eye contact (irritant), of ingestion, of inhalation. InhalationRemove to fresh air. MSDS Name: Sodium thiosulfate Catalog Numbers: AC202870000, AC202870010, AC202870025, AC202870050, AC202875000, S75222, S78930-1, S78930-2, S78930-3, S78930-4, S79809, NC9417189, . The phase IV clinical study analyzes what interactions people who take Sodium thiosulfate and Venofer have. Drug interactions are reported among people who take Sodium thiosulfate and Venofer. Case Reports/Series Dialysis Patients It is widely used to remove chlorine from swimming pools. Sodium thiosulfate is used to treat a fungal infection of the skin called tinea versicolor. It is also called sodium hyposulfite or 'hypo'. Sodium thiosulfate is an important inorganic salt with several medical uses. INHALATION: Inhalation of product dust or mist may irritate the . Do not put on irritated skin. Calciphylaxis is an obliterative vasculopathy that causes ischemia and necrosis of the skin, subcutaneous fat, visceral organs, and skeletal muscle. STS is an inorganic salt that has been used intravenously for decades, initially for the treatment of cyanide poisoning. 5. Sodium thiosulfate (STS) is an industrial chemical which also has a long medical history. Additional data may be . This medicine may be used for other . sodium thiosulfate is used. To make the 10% ST solution, just add 10 grams Sodium Thiosulfate to 90 grams (ratio 1:9) of water and you will have the 10% solution so you can use drops if you want. Common concerns See how this product scores for common concerns. Methaemoglobin concentration should not exceed 30-40%. Get medical attention immediately if symptoms occur. Talk with your doctor before you use other drugs or products on your skin. [1] Sodium thiosulfate is a skin, eye, nose and throat irritant. By definition, sodium thiosulfate is an inorganic sodium salt made of sodium and thiosulfate ions. What is the purpose of adding sodium thiosulfate? A range of approximately 2 to 7 parts sodium thiosulfate to neutralize one part chlorine is generally suggested. Sodium thiosulfate is used to lower chlorine levels in swimming pools and spas following super chlorination. Sodium thiosulfate (STS) (Na 2 S 2 O 3) is used to prevent and treat cyanide poisoning ( 7 ). It has a NFPA Rating of 1,0, 0 for health, fire and reactivity, respectively. Skin Contact: Wash skin with soap and plenty of water for at least 15 minutes. The painful skin ulcers improved significantly soon after treatment, with a slight reduction in the calcium-phosphorus product. An advantage is that the substance is very reasonable, easy to use and readily available. Do not put on irritated skin. Sodium thiosulfate is an antifungal medicine that fights infections caused by fungus. It may be given to you for other reasons. Find patient medical information for sodium thiosulfate intravenous on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Salicylic acid helps your skin absorb the sodium thiosulfate. What do I need to tell my doctor BEFORE I take Sodium Thiosulfate? It demonstrated beneficial effects in most patients, with partial to complete resolution of skin lesions and reductions in radiotracer activity on bone scans. What is the risk of sodium thiosulfate? This type of poisoning can occur if you are exposed to smoke from a house or industrial fire, if you swallow or breathe in cyanide, or if you get cyanide on your skin. It has since been approved for the treatment of certain rare medical conditions. Fungal infections of the skin [ edit] Foot baths of sodium thiosulfate are used for prophylaxis of ringworm. Remove contaminated clothing and shoes. Skin: Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Sodium thiosulfate, which is also referred to as sodium sulphate, is a chemical compound which has the formula Na 2 S 2 O 3. Sodium thiosulfate 7772-98-7 >95 4. Exposure to moist air or water. sodium thiosulfate uses. Formula and structure: The chemical formula of sodium thiosulfate is Na 2 S 2 O 3 and its molar mass is 158.11 g/mol. Uses of Sodium Thiosulfate It is used as an antidote to cyanide poisoning. Use of sodium thiosulfate in the treatment of calciphylaxis has been described primarily in case series and case reports. The skin over his . These injuries evolve to extensive superficial necrosis of the skin overlying the panniculitis, with ulceration, overinfection and consequent sepsis. It is a calcium-chelating agent and has many medical uses in removing toxic substances from the body. . sodium thiosulfate uses. Be sure to use Sodium thiosulfate lotion for the full course of treatment. However, for prophylactic purposes for example, to prevent the occurrence of an allergic reaction, thiosulfate is useless. Sodium Thiosulfate, Anhydrous Sodium Hyposulfite, Anhydrous O7772-98-7 Na 2 S 2 3 98.5 Trade Secret Statement: Not applicable. The dose may be 2 ml of 0.17 M (a solution of 4 ml 10% sodium thiosulfate and 6 ml sterile water for injection). Uses and Benefits of Sodium Thiosulfate Sodium thiosulfate is a powerful detoxing agent to remove mercury and other heavy metals from the body. If you use sodium thiosulfate and salicylic acid too often . SODIUM THIOSULFATE Monographs. First-aid measures Eye ContactRinse immediately with plenty of water, also under the eyelids, for at least 15 minutes. Do not get this medicine in your eyes. Sodium thiosulfate is an antifungal medicine that fights infections caused by fungus. If you use topical products too often, your condition may become worse. How does sodium thiosulfate neutralize chlorine? For the process of tanning in the leather industry, sodium thiosulfate is used. In addition, Sodium thiosulfate is used in calciphylaxis in hemodialysis patients with end-stage kidney disease. It is also available as its pentahydrate salt (Na 2 S 2 O 3 .5H 2 O), with a molar mass of 248.18 g/mol. Current treatment modalities used to counteract this pathology are not entirely effective. This is . Skin manifestations such as . Safety issues The medical uses of sodium thiosulfate include treatment of cyanide poisoning and pityriasis. Depending on the medical condition being treated, the salt can be injected, taken orally, or applied to the skin. Wash, rinse and dry the affected areas before applying this medicine. In particular, the sodium thiosulfate can be used to treat metastatic, dystrophic, iatrogenic, or idiopathic calcifications, calcifications associated with calciphylaxis, or subcutaneous ectopic ossifications. 2013;6(5):41-44.) Reported acid-base disturbance . Total parathyroidectomy was carried out 6 months after the STS therapy, which successfully solved hyperparathyroidism and the high calcium-phosphorus profiles. Exposure to light. Skin inflammation is characterized by itching, scaling, reddening, or, occasionally, blistering. Salicylic acid and sodium thiosulfate topical (for the skin) is a combination medicine used to treat a skin infection called tinea versicolor, that appears as white patches on the skin. It simply reacts and forms sodium hydrogen sulfate or sodium bisulfate which is an inactive . Intravenous sodium thiosulfate has been used successfully to treat calciphylaxis and tumoral calcinosis in patients who are undergoing renal dialysis. EYES: Dust, solutions or mist may irritate or burn the eyes and cause temporary conjunctivitis. . . It often manifests with skin necrosis. Sodium nitrite and sodium thiosulfate is used in an emergency to treat cyanide poisoning. Wash clothing before reuse. extruded aluminum process / best lat pulldown attachment / sodium thiosulfate uses. Talk with your doctor before you use any other medicines or cleansers on your skin. It is also used with another medicine in the emergency treatment of cyanide poisoning. An exothermic reaction gives off heat, like our hot pak. In the method of the invention, dialysis solution . Additional data may be necessary to further define its role in this condition. Sodium thiosulfate dose in the Management of delayed calcium extravasation (calcinosis cutis) (off-label): IV: 12.5 g over 30 minutes; may increase the dose gradually to 25 g 3 times per week; monitor for non-anion gap acidosis, low calcium, and severe nausea. ABSTRACT: The use of sodium thiosulfate has emerged as a promising treatment for calciphylaxis, albeit inconclusively in terms of efficacy and variable outcomes. To investigate whether the reactivity difference between the 2 gold salts was due to differences in bioavailability, some experiments were carried out. Eye Contact: Check for and remove contact lenses, if present and easy to do. Uses of Sodium Thiosulfate: It is used to treat cyanide poisoning . It is used in photographic film processing. Remove contaminated clothing and shoes. Sodium thiosulfate is to be administered only by or under the immediate supervision of your doctor. This pentahydrate of sodium thiosulfate is described by the following chemical formula: Na 2 3,8,9 The use of high bicarbonate dialysate may resolve sodium thiosulfate-induced metabolic acidosis.8 Because each 25 g of sodium thiosulfate in 100 mL of normal saline contains 4.8 g of sodium, the sodi um load should be considered; increases in serum sodium According to Strazzula et al: "The mechanism of sodium thiosulfate in the treatment of calcium-related disorders is thought to be multifactorial. Follow the directions on the prescription label. These are in a 2:1 ratio. Find patient medical information for sodium thiosulfate on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. SODIUM THIOSULFATE (SOE dee um thi oh SUHL feyt) is used to treat cyanide poisoning. It is also used as a topical antifungal agent for tinea versicolor (pityriasis versicolor), possibly in combination with salicylic acid; [17] [18] and for other fungal infections of the skin. Abstract: The invention provides a source of sodium thiosulfate via the dialysate used to cleanse the bool of toxic and metabolic waste in the patients undergoing hemodialysis, peritoneal dialysis, or gastro-intestinal dialysis for treatment of end-stage or near end-stage chronic renal disease. LOW Cancer LOW Allergies & Immunotoxicity LOW Developmental and Reingredientive Toxicity LOW Use Restrictions Ingredient concerns CONCERNS DATA SOURCES Products with this Ingredient Multiple, additive exposure sources Data gaps Ecotoxicology Sodium thiosulfate has been used off-label for nephrotoxicity prophylaxis during cisplatin therapy and for treatment of extravasation . May cause eye, skin, and respiratory tract irritation. ( J Clin Aesthet Dermatol . It is also a topical anti-fungal such as can be used for ringworm. Sodium thiosulfate is an antifungal medicine that fights infections caused by fungus. Calciphylaxis is vasculopathy characterized by ischemia and painful skin necrosis due to calcification and intimal fibroplasia of thrombosis of the panicular arterioles. Salicylic acid and sodium thiosulfate topical (for the skin) is a combination medicine used to treat a skin infection called tinea versicolor, that appears as white patches on the skin. Sodium thiosulfate is used to reduce iodine back to iodide before the iodine can complex with the starch to form the characteristic blue-black color. It is also used in the extraction of gold. By Posted westside harp stability In best candle warmer for bath and body works Sodium Thiosulfate, Anhydrous Hypo: Sodium Hyposulfate SX0820 Analytical reagent. with sodium thiosulfate treatment of calciphylaxis in hemodialysis patients. A chemical that reacts with excess chlorine used for purification, disinfecting, or some other purpose. If treating hands, wash hands before use only. Sodium thiosulfate is an irritant to the skin, eyes, and respiratory tract, although such effects tend to be mild unless one is exposed to large quantities of sodium thiosulfate dust, mist, or solutions. 6-10 The treatment is generally considered to be safe, 11 with minimal adverse effects other than occasional nausea. Sodium thiosulfate is used as treatment due to its antioxidant . As a dechlorinating agent for water bodies like swimming pools, ponds, etc. It is also used in some vital tests for kidney . Sodium sulfite (sodium sulphite) is a soluble sodium salt of sulfurous acid . Salicylic acid helps your skin absorb the sodium thiosulfate. In case of large amount of chemical ingestion or inhalation, it can be hazardous. Subsequently it proved to be effective in treating calcium-mediated disorders. Step 1: Na 2 CO 3 + 2SO 2 + H 2 O 2NaHSO 3 + CO 2 Sodium carbonate reacts with sulfur dioxide and water to produce sodium bisulfite and carbon dioxide. Sodium thiosulfate, or sodium thiosulphate, is a colorless, water-soluble salt. If you use Sodium thiosulfate and salicylic acid too often, your skin problem may become worse. Once all the thiosulfate is consumed the iodine may form a complex with the starch. In the mining of gold sodium thiosulfate is an important component. Sodium thiosulfate is an antifungal medicine that fights infections caused by fungus. 800-424-9300 CHEMTREC (USA) 613-996-6666 CANUTEC (Canada) 24 Hours/Day: 7 Days/Week 3/4/2003 5/3/2004 . [19] Side effects [ edit] First Aid Procedures: . Slightly hazardous in case of skin contact (irritant . Sodium thiosulfate is a reducing agent. Wash skin with soap and plenty of water for at least 15 minutes. Skin ContactWash off immediately with plenty of water for at least 15 minutes. He was completely devoid of scalp and body hair (alopecia totalis); had salt and pepper like appearing skin over back and legs; pinched nose; thick and tight skin in hands and feet. Drug information provided by: IBM Micromedex Descriptions Sodium thiosulfate may be used to lessen some of the side effects of cisplatin (a cancer medicine). Since it is employed as a Sodium thiosulfate (Na2S2O3) can be used to neutralize or remove residual chlorine. May be hazardous in case of inhalation. Use of sodium thiosulfate in the treatment of calciphylaxis has been described primarily in case series and case reports and in a single retrospective review, it demonstrated beneficial effects in most patients, with partial to complete resolution of skin lesions and reductions in radiotracer activity on bone scans. Gold sodium thiomalate is used for treatment of rheumatoid arthritis, a treatment with a high frequency of adverse skin reactions. A new treatment reported for calciphylaxis, is the use of intravenous sodium thiosulfate. It is used in several pharmaceutical preparations. Wash clothing before reuse. Sodium thiosulfate anhydrous 7772-98-7 100 Toxicological Data on Ingredients: Sodium thiosulfate anhydrous LD50: Not available. If symptoms of cyanide toxicity recur, the doses of nitrite and thiosulfate may . Sodium thiosulfate is a relatively non-toxic substance. Research in this field has been limited by a paucity of samples due to the rarity of the disease. Talk with the doctor. To do this, we dissolve sodium carbonate in. The drug eliminates the unpleasant allergic manifestations, cleanses the skin, facilitates breathing, improves the work of the digestive system. Sodium thiosulfate (STS) was used for treatment in this case. Do not treat a poisoning or overdose yourself. It is also known to limit adverse effects of certain chemotherapies such as cisplatin ( 8 ). Sodium Thiosulfate trade name is Sodium Thiosulfate, Na2S2O3.5H20 and it's a white crystalline product. Sodium thiosulfate appears to be a viable first-line treatment for calciphylaxis and should be seriously considered early in the course of treatment. It . Is Sodium thiosulfate bad for my skin? Salicylic acid and sodium thiosulfate topical (for the skin) is a combination medicine used to treat a skin infection called tinea versicolor, that appears as white patches on the skin. Sodium thiosulfate administered by the topical route can enable the treatment of any ectopic calcification, whatever its origin. Sodium thiosulfate is an antifungal medicine that fights infections caused by fungus. It is used as an antifungal medicine on the skin to treat the infections caused by fungus. Sodium thiosulfate, 0.1 N standard solution Revision Date 24-Dec-2021 Conditions to Avoid Excess heat. DBL Sodium Thiosulfate dosage. Allergy sodium thiosulfate is indicated for acute process. Sodium Thiosulfate is an inorganic salt. Incompatible Materials Acids Hazardous Decomposition ProductsSulfur oxides, Sodium oxides Hazardous Polymerization Hazardous polymerization does not occur. Abstract. To neutralize 1 liter of a 200 ppm chlorine solution, approximately 0.4 - 1.4 grams of sodium thiosulfate would be required. For our purposes in the pool, sodium thiosulfate is used to reduce the amount of chlorine. The authors thank the Skin and Allergy Research Unit at Chulalongkorn University . To such signs, indicating the development of the early stage of psoriasis, refers to the appearance on the skin of unusual seals . Hence, it is important to use appropriate personal protection equipment (PPE), proper handling protocols, and well-ventilated space while working on the chemical. The medical uses of sodium thiosulfate include treatment of cyanide poisoning and pityriasis. Call a physician if symptoms occur. The reaction of sodium thiosulfate and hydrochloric acid generates sulfur dioxide gas, which is a skin and eye irritant. Sodium thiosulfate also used in leather tanning. . Get medical aid if irritation develops or persists. If a poisoning or overdose occurs, get emergency help. Salicylic acid and sodium thiosulfate topical (for the skin) is a combination medicine used to treat a skin infection called tinea versicolor, that appears as white patches. Sodium thiosulfate is used in gold mining, water treatment, analytical chemistry, the development of silver-based photographic film and prints, and medicine. Medical uses of Sodium thiosulfate Patrick L. McGeer*, Edith G. McGeer and Moonhee Lee Kinsmen Laboratory of Neurological Research, University of British Columbia, VancouverBC V6T 1Z3, Canada Background Sodium thiosulfate (Na 2 S 2 O 3, STS) is an industrial compound which has a long history of medical use. It is a multi-purpose chemical used in several applications such as in metal refining, photography, gold mining, as an anti-chlorine agent, and an antioxidant. An EPA toxicity study indicated that sodium thiosulfate is not very toxic to aquatic species. S Karthik, A Bhatt, 1 and T Babu Author . Sodium thiosulfate dressings facilitate healing of refractory cutaneous ulcers of calcinosis cutis. Fowler later initiated the use of 0.5% w/w gold sodium thiosulfate (GSTS) in petrolatum as a test preparation to determine the presence of contact allergy to gold. Get medical attention. Indications for the use of sodium thiosulfate in psoriasis are the appearance of the first signs of the disease, which indicate that the defenses of the patient's body are reduced, and the disease is actively coming. . Salicylic acid helps your skin absorb the sodium thiosulfate. It was originally used as an intravenous medication for metal poisoning. Adult: To be given after 300 mg of sodium nitrite has been admin over 5-20 min: 12.5 g of sodium thiosulfate (50 ml of a 25% solution or 25 ml of a 50% solution) given over 10 min. If you get Sodium thiosulfate lotion in your eyes, immediately flush with cool tap water. 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