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Cerium dioxide as a bulk crystal mainly consists of Ce 4+, but reduction in size to nano-dimensions significantly enhances the relative amount of Ce 3+ 25 resulting in higher catalytic effects. The oxide form of the rare earth element cerium, found in the lanthanide series of elements, has the ability to cycle between its cerium (III) and cerium (IV) oxidation states, due to a lattice structure, with a high tolerance for reversible oxidation/reduction [30]. Cerium oxide nanoparticles (CeNPs) exhibit antioxidant properties both in vitro and in vivo. Biodiesel is mixed with cerium oxide nanoparticles (CeO 2) nanoparticles using an ultrasonicator and a magnetic agitator to ensure that the particles are homogeneous and achieve uniform suspension. In 2010, Babu et al. Since cerium oxide nanoparticles (CNPs) exhibit remarkable antioxidant capacities, the objective is to develop an innovative coating to enhance CNPs biocompatibility without disrupting their antioxidant capacities or enhance . Cerium oxide-polymer fiber patch acts an antioxidant against reactive oxygen species. Cerium oxide nanoparticles (CNPs) represent a promising class of antioxidant nanoparticles with potential therapeutic value. Although many antioxidants are tested in preclinical studies, no treatment is currently available for stroke patients. Elemental cerium is a flexible and malleable lustrous metal. Levan coated cerium oxide nanoparticles (LCNPs) with the enhanced antioxidant activity were successfully synthesized and characterized. Since it is known, oxygen vacancies in the particle surface inhibit ROS by oxidation or reduction reactions [9]. Levan and their derivatives are attractive for biomedical applications attributable to their antioxidant, anti-inflammation and anti-tumor properties. Cerium oxide nanoparticles (CeONP), having potent antioxidant properties, are highly promising nanomaterials for treatment of diseases in which oxidative stress from excessive reactive oxygen species (ROS) plays a critical role in the pathogenesis and progression. (TNF) and a decrease in the activity of the antioxidant catalase. These eects were also seen in cell culture, where cerium oxide nanocrystals were able to protect broblasts against oxidative stress induced by expo-sure to hydrogen peroxide. Modern and efficient tactics are required to boost agricultural output beyond facing stresses. In fact CeO 2 nanoparticles are most commonly used in the biomedical field as catalysts [79] and antioxidants [78]. Cerium Oxide Very recently, cerium oxide (CeO2 ), a rare-earth oxide found in the lanthanide series of the periodic table, has been increasingly used as a nanotherapeutic material. Quantitative analysis of the antioxidant capacity of CeO 2-x using gas chromatography and a luminol test revealed that 2 mol of H 2 O 2 reacted with every mole of cerium (III), suggesting that the reaction proceeds via a Fenton-type mechanism. Cerium oxide nanoparticles (CeO 2 NP) are rare earth metal oxide material of the lanthanide elements, which have excellent biocompatibility and unique antioxidant capacity 13,14,15. The dispersion of cerium oxide may be a combination of cerium oxide and a specific dispersion medium and as such, can exhibit effects of moisturizing the skin and . Cerium metal is iron-gray in color and is highly reactive. Their antioxidant properties make them highly effective as scavengers for the superoxide anions or reactive nitrogen species (RNS) present in biologic milieus [ 25, 26 ]. In testing with hydrogen peroxide, a strong oxidizing agent, the researchers found their most effective cerium oxide III nanoparticles performed nine times better than a common antioxidant, Trolox, at first exposure, and held up well through 20 redox cycles. Ceria exists in a trivalent state ( +3) or a tetravalent state ( +4) and may change between the two in a redox reaction. Introduction Myocardial ischemia occurs when the supply of blood to the heart is impeded, often due to coronary artery occlusion [ 1 ]. A better knowledge of the interplay between oxidative stress and amyloidogenesis is crucial for the understanding of both, aging and age-related neurodegenerative diseases. Antioxidant cerium oxide nanoparticle hydrogels for cellular encapsulation Oxidative stress and the resulting radical by-products cause significant toxicity and graft loss in cellular transplantation. Cerium dioxide nanoparticles (CeO2 NPs, nanoceria) due to their remarkable properties are perspective nanomaterials in the study of the . HeLa cells express AQP3, 6, 8, and 11, able to facilitate H 2 O 2. X-ray diffraction (XRD) data shows that the synthesized particles are single phase. Further, from the investigation, it is well known that cerium oxide nanoparticle act as a catalyst, which mimics the feature of antioxidant enzyme superoxide dismutase (SOD) and scavenges ROS or free radicals. Cerium oxide (CeO2) is amongst the most used rare earth compounds [78]. have been investigated for their antibacterial and antioxidant activity. Seed priming with nanoparticles (NPs) is a . Among inorganic antioxidants, cerium oxide nanoparticles (CeNPs) are reported by Self and colleagues to exhibit scavenging of superoxide radicals and degradation of hydrogen peroxide under in vitro, in vivo, and other animal models (Korsvik et al., 2007; Heckert et al., 2008a; Karakoti et al., 2009). AQP3, 6, and 8 are expressed in the plasma membrane and intracellularly, while AQP11 resides only in intracellular structures. The FSP technique allows for a one-step, precise stoichiometric synthesis of the doped nanoceria. 3. Researchers are now harnessing the catalytic repertoire of CNPs to . Crop production is continuously threatened by various environmental stresses. The higher . higher than that of the standardly used antioxidant, Trolox. As a proof-of-concept design, ultrasmall cerium oxide nanoparticles are encapsulated into the functionalized MSNs and released out within 10 min scavenging more than 80% of the H 2 O 2 in an ROS-rich environment. Since cerium oxide nanoparticles (CNPs) exhibit remarkable antioxidant capacities, our objective is to develop an innovative coating to enhance CNPs bio-compatibility without disrupting their. In this study, we investigated whether cerium oxide nanoparticles (CeO2-NPs), a promising antioxidant nanomaterial, may contrast retinal vascular alterations induced by oxidative damage in vitro and in vivo. Ceria (CeO 2 NPs) nanostructures also have antioxidant or pro-oxidant properties depending on the experimental condition and ceria nanomorphology [ 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34 ]. [104] fabricated CeO 2 NPs for enhanced bronchial cancer bioimaging via codoping with an emitter (erbium) and sensitizer . 15,18 Due to the high reactive surface area provided by the fluorite crystalline lattice structure of cerium oxide, it helps them in the . Cerium oxide nanoparticles of 2-6 nm have proven to demonstrate superoxide dismutase (SOD) mimetic activity, emphasised by ferricytochrome C assay [ 24 ]. in the last few decades, nanotechnology has been employed throughout biomedical research studies. Researchers are now harnessing the catalytic repertoire of CNPs to develop potential new treatment modalities for both . 1 - 3 cerium oxide nanoparticles (cnps), consisting of cerium atoms linked by oxygen atoms, have been used in commercial, industrial, and biological applications. The antioxidant activity of nanoceria is often attributed to its intrinsic properties, it is made of divalent oxygen anions (O2) as well as tetravalent cerium cations (Ce4+) with surface trivalent cerium cations (Ce 3+). Antioxidant activity of cerium dioxide nanoparticles and nanorods in scavenging hydroxyl radicals - RSC Advances (RSC Publishing) Cerium oxide nanoparticles (CeNPs) have been shown to exhibit antioxidant capabilities, but their efficiency in scavenging reactive oxygen species (ROS) and the underlying mechanisms are not yet well understood. Smaller diameter nanocrystals containing more cerium (III) were found to be more reactive toward H 2 O 2. Further, using an in vivo model of mild lateral fluid percussion brain injury in the rat, we report that cerium oxide nanoparticles also preserve endogenous antioxidant systems, decrease macromolecular free radical damage, and improve cognitive function. Polymer/cerium oxide patch prevents agonist induced cardiac hypertrophy 1. Here, the engineering of an auto-catalytic, antioxidant, self-renewing cerium oxide nanoparticle (CONP)-composite hydrogel is reported. Consequently, during the last few years antioxidant substances, such as superoxide dismutase (SOD), resveratrol, colchicine, eugenol, and vitamins E and C have received . Cerium(IV) oxide, also known as ceric oxide, ceric dioxide, ceria, cerium oxide or cerium dioxide, . For the in vivo experiments, the light damage (LD) animal model of Age-Related Macular Degeneration (AMD) was used and the CeO2-NPs were intravitreally injected. Synthesis of these nanoparticles can be performed very easily by utilizing chemical or biological Finally, over repeated cycles, the oleic acid coated CeO 2 was found to be the most This study aimed to analyze the effect of cerium oxide nanoparticles (CNPs) presenting antioxidant activity on AQP functioning. Monodispersed cerium oxide nanoparticle has been synthesized by microwave-mediated hydrothermal as well as microwave-mediated solvothermal synthesis. Cerium oxide nanoparticles with antioxidant capabilities and gadolinium integration for MRI contrast enhancement Authors Peter Eriksson 1 , Alexey A Tal 2 3 , Andreas Skallberg 1 , Caroline Brommesson 4 , Zhangjun Hu 1 , Robert D Boyd 5 , Weine Olovsson 2 , Neal Fairley 6 , Igor A Abrikosov 2 3 , Xuanjun Zhang 7 , Kajsa Uvdal 8 Affiliations Few plant-mediated syntheses have been conducted, where CeCl 3 [80] and cerium (III) nitrate hexahydrate [78] were used as precursors. "The next logical step for us is to do some passive targeting," Colvin said. PDF | On Feb 16, 2022, Debanjan Dutta and others published Cerium Oxide Nanoparticles as Antioxidant or Pro-oxidant Agents | Find, read and cite all the research you need on ResearchGate Monodispersed cerium oxide nanoparticle has been synthesized by microwave-mediated hydrothermal as well as microwave-mediated solvothermal synthesis. Lung sections of mice exposed to CeO 2 NPs showed a dose-dependent infiltration of inflammatory cells consisting of macrophages and neutrophils. It is also known as a strong oxidizing agent and exists as cerium oxide in association with oxygen atoms. The XRD patterns of the CeNPs samples CeOx, CeOx:Gd9%, CeOx:Gd19% and CeOx:Gd46% were compare to a reference sample of cerium oxide crystal in Fig. This is due to the self-regeneration of their surface, which is based on redox-cycling between 3+ and 4+ states for cerium, in response to their immediate environment. Cerium oxide nanoparticles have gained a lot of attention as a potential future candidate for ending various kinds of problems by exhibiting redox activity, free radical scavenging property, biolm inhibition, etc. Considering that cerium oxide has high redox capacity and can be doped by trivalent ions, the third mentioned option has been chosen to increase the oxygen vacancies and consequently the antioxidant activity. All the synthesized samples exhibit the three most prominent peaks characteristic for cerium oxide, corresponding to the [111]-, [220], and [311]-planes in the cubic fluorite crystal structure 45. Cerium oxide is considered to be a lanthanide metal oxide and is used as an ultraviolet absorber [2], [3], catalyst [4], [5], polishing agent, gas sensors etc [6], [7], [8], [9], [10]. Cerium oxide nanoparticles (nanoceria, CNPs), are widely applied in chemical mechanical polishing and planarization processes [ 6 ], in the development of corrosion protection coatings for metals and alloys [ 7] and in diesel fuel oxidation catalysis [ 8 ]. Similarly, the . The particles were synthesized via rapid flame spray pyrolysis (FSP) of cerium 2-ethylhexanoate premixed with tetraethyl orthosilicate and tantalum (V) ethoxide for Si and Ta dopings, respectively. A metal oxide nanoparticle called cerium oxide was added to an orange peel oil methyl ester to study its impact on the diesel engine. Oxidative stress induced by the overproduction of free radicals or reactive oxygen species (ROS) has been considered as a key pathogenic mechanism contributing to the initiation and progression of injury in liver diseases. Cerium oxide nanoparticles (CeO 2 NPs), used as a diesel fuel catalyst, can be emitted into the ambient air, . Recently, many studies reported that nanotechnology can enhance plant growth and development under stress and non-stress conditions, contributing to agricultural sustainability. For commercial purpose, nanoceria plays a vital role in cosmetic products, consumer products, instruments and high technology. Cerium; Cerium anomaly . Cerium oxide nanoparticles (CeO2 NPs) are a sought-after material in numerous fields due to their potential applications such as in catalysis, cancer therapy, photocatalytic degradation of pollutants, sensors, polishing agents. 4 - 6 cnps are considered as one of the most interesting nanomaterials due to their It exists as either cerous (Ce 3+, trivalent state) or ceric (Ce 4+, tetravalent state) in the form of compounds [ 1 ]. SEM and TEM analysis suggest that particle synthesized by microwave-mediated solvothermal method are less agglomerated. The prepared cerium salt solution is mixed with aqueous plant extract and stirred the mixture at 80 C for 4-8 h. After a certain period, a yellowish precipitate of CeO 2 NPs was formed. In vitro toxicology study of the . Additionally, oxygen vacancies in the lattice structure allow for alternating between CeO2 and CeO2x during redox reactions. Recently, nanoceria has been used as a colorimetric indicator for antioxidants activity due to the color changes induced by the modifications of cerium oxidation states at nanoparticle surface [ 25, 26, 27 ]. Due to the easily reversible oxidation states of cerium (Ce 3+ and Ce 4+) at the nanoscale, CNPs scavenge excessive reactive oxygen and nitrogen species in a self-regenerative manner. Nanoceria is a prospective replacement of zinc oxide and titanium dioxide in sunscreens, as it has lower photocatalytic activity. See also. 98 The ability of CeO 2, also known as nanoceria, to switch between mixed oxidation states is similar to that of biological antioxidants. Previously, catalytic cerium oxide nanoparticles (CNPs, nanoceria, CeO2-x NPs) have been widely utilized for chemical mechanical planarization in the semiconductor industry and for reducing harmful emissions and improving fuel combustion efficiency in the automobile industry. A dispersion of cerium oxide according to an embodiment of the present disclosures shows excellent effects of enhancing the skin barrier, skin moisturizing and/or blocking fine dust, and a cosmetic composition comprising same. Next, the synthesized CeO 2 NPs were separated using centrifugation, washed with double-distilled water, and the precipitate was calcined at 500 C for 2 h. This study provides a novel design of a free-blockage ROS-controlled release system loaded with ROS-scavenging nanoparticles for the . X-ray diffraction (XRD) data shows that the synthesized particles are single phase. It was established that CeO 2 nanoparticles have the capacity to initiate their mechanism by the modulation of the oxygen environment [ 28 ]. ceonps synthesized at alkaline ph showed almost no toxic effect on zebrafish larvae; on the contrary, ceonps synthesized at acidic ph were found to be toxic, leading to mortality, morphological changes, and abnormal swimming behavior of the larvae and altered levels of reactive oxygen species (ros), mitochondrial membrane potential, and dna Oxidative stress is known to be associated with a number of degenerative diseases. Previously, catalytic cerium oxide nanoparticles (CNPs, nanoceria, CeO2-x NPs) have been widely utilized for chemical mechanical planarization in the semiconductor industry and for reducing harmful emissions and improving fuel combustion efficiency in the automobile industry. 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