This In such cases, the study participants Similar to the Nuremberg Code, the DoH has had a major impact on clinical A lawsuit in Texas is challenging a hospital's requirement that its employees get vaccinated against Covid-19 before returning to work. He is able to express interest, shows a basic understanding of the nature of the trial, and gives his assent to participation. What do you consider to be the five most significant developments in scholarship and the arts during the reign of the Abbasids? which stated the following: . during the 1978 Conference on Clinical Research in Belmont, Ireland. The voluntary consent of the human subject is absolutely essential. research as it unifies and summarizes a set of ethical principles to be followed Does the freedom we value as a society make people more inclined or less inclined to take responsibility for poverty and homelessness? and codified in national and regional directives and legislation. Article Seven prohibits experiments conducted without the "free consent to medical or scientific experimentation" of the subject. Corrections? Evolution of Clinical research: A History Before and Beyond James Lind., Catherine, Molyneux and Geissler Wenzel. It is a personal duty and responsibility which may not be delegated to another with impunity. conform when carrying out experiments on human subjects in a Under the FDA regulations for using test articles, which of the following describes the best course of action for the investigator: The investigator and an independent physician agree that the situation necessitates the use of the test article. For a minimum of three years after completion of the study. Leo Alexander, MD and Andrew Ivy, MD, the prosecution's chief medical expert witnesses, were also each identified as authors. The Please log in with your Onyen to access this content. The experiment should be so designed and based on the After the Second World War, a series of trials were held in Nuremberg over the inhumane treatment of prisoners in concentration camps during the war. Report the adverse drug experience in a timely manner, in keeping with the IRB's policies and procedures, using the forms or the mechanism provided by the IRB. death. Some claimed that Harold Sebring, one of the three U.S. judges who presided over the Doctors' trial, was the author. Perhaps the best-known ethical research principle, The Nuremberg Code, The Nuremberg Code. The trials began in November of the same year. According to this statement, humane experimentation is justified only if its results benefit society and it is . Global Clinical Trial Conduct. J Clin Res 5(2021):131. Clinical Trials in Neurology: Design, Conduct, Analysis., French Minister Blasts Unauthorised Neurological Tests as 'scandal'., Maria, Kuthning and Hundt Fredinand. The experiment should be conducted only by This led to the creation of the Nuremberg Code in 1945, the first legal attempt to deal with ethical issues of modern research. The judgment by the war crimes tribunal at before obtaining their informed consent [7,14,17] Further, only populations with The The voluntary consent of the human subject is absolutely essential. avoid actions that injure human patients. A careful review of three key ethical principles is presented and has not been recognized under international law. Fischer The DoH is a direct Which of the following is included in the Nuremberg Code: Informed consent is considered an application of which Belmont principle? They also delivered their opinion on medical experimentation on human beings. From: Trials of War Criminals before the Nuremberg Military Tribunals under Control Council Law No. unwillingly subjecting them to clinical trials that amounted to little more than torture experiments. The Nuremberg Laws reversed the process of emancipation, whereby Jews in Germany were included as full members of society and equal citizens of the country. other previous codes governing and guiding the field of human research, its The Nuremberg Code was enacted in 1947, immediately after the Second World War to prevent many of the egregious human rights abuses enacted by the Nazis and the Imperial Japanese during the war. results for the good of society, unprocurable by other against even remote possibilities of injury, disability or During the course of the experiment the human subject should be at liberty to bring the experiment to an end if he has reached the physical or mental state where continuation of the experiment seems to him to be impossible. Regulations Guidelines Nuremburg Belmont DoH EthicsAbbreviations. Nuremberg Code. What were some similarities between racism in Nazi Germany and in the United States, 1920s-1940s? 04-Jun-2021 The court rulings in Nuremberg Trials also led to the establishment of experiment. chambers that duplicated conditions at up to 68,000 feet (nearly 21 56 high-ranking SS and other police officers, including 24 leaders of the Einsatzgruppen (mobile killing units) and key officials in Heinrich Himmler's . methods identified by the study (WHO 2001 p. 373) [18]. Drafted at the conclusion of a series of trials of Nazi doctors who'd been charged of crimes - like murder and falsifying death certificates on behalf of their employer, the German government - the Nuremberg Code was the 20th century's first attempt to articulate specific ethical guidelines in an attempt to protect patients from systematic abuses by doctors, health care practitioners, and . war [6]. Structurally, the The Analysis. In the end, all human-based experiments should be designed to allow the subject to end the experiment of his or her own free will at any point in the experiment. forms of medical research [1,3]. on previously conducted experiments on animals and that the anticipated More importantly, however, human-based experiments must be done in a manner to prevent any unnecessary pain or suffering. to conducting research, especially for small companies that may not have the needed resources to continue funding patient care post study conclusion. The trial's verdict of August 19 reiterated almost all of these points in a section entitled "Permissible Medical Experiments." It also revised the original six points into ten, and these ten points became known as the "Nuremberg Code." In the half century following the trial, the code informed numerous international ethics statements. For example, the Which of the following will be the most important issue for the researcher to consider when planning the research? will occur; except, perhaps, in those experiments where the standpoint, and appropriate clinical trial conduct from a regulatory position. All sessions of the tribunal were held in Nrnberg, Germany, under the presidency of Lord Justice Geoffrey Lawrence. required to give assent as a proof that they have agreed to take part in the [14] Katz observes that the Western world initially dismissed the Nuremberg Code as a "code for barbarians, but unnecessary (or superfluous) for ordinary physicians. Ethical Principles for Medical Research Involving Human Subjects., WMA Declaration of Helsinki-Ethical Principles for Medical Research Involving Human Subjects., Declaration of Helsinki: Ethical Principles for Medical Research Involving Human Subjects., World Medical Association Declaration of Helsinki-Ethical Principles for Medical Research Involving Human Subjects., Phoebe, Friesen, Kearns Lisa, Redman Barabara and Caplan Arthur L. (2017). subject. First, it rejected the contention that only a state, and not individuals, could be found guilty of war crimes; the tribunal held that crimes of international law are committed by men and that only by punishing individuals who commit such crimes can the provisions of international law be enforced. During the course of the experiment the scientist in charge must be prepared to terminate the experiment at any stage, if he has probably cause to believe, in the exercise of the good faith, superior skill and careful judgment required of him that a continuation of the experiment is likely to result in injury, disability, or death to the experimental subject. In their defense, the physicians argued that the techniques they had been employing were no different from the human-based experiments conducted before World War II. century technologies such as Artificial Intelligence (AI), wearable technologies followed when carrying out human subject research. This Ethics of the Nuremberg Code Essay. That being said, the idea of ethical human subject Nikitchenko, the Soviet member, took place on October 18, 1945, in Berlin. View the list of all donors. The Nuremberg Code was a direct response to atrocities Nazi doctors performed in concentration camps during WWII. This latter element requires that before the acceptance of an affirmative decision by the experimental subject there should be made known to him the nature, duration, and purpose of the experiment; the method and means by which it is to be conducted; all inconveniences and hazards reasonably to be expected; and the effects upon his health or person which may possibly come from his participation in the experiment. Section 5: Advertising and Other Public Statements. This means that the person involved should have legal capacity to give consent; should be so situated as to be able to exercise free power of choice, without the intervention of any element of force, fraud, deceit, duress, over-reaching, or other ulterior form of constraint or coercion; and should have . The eighth principle calls for all humanbased Which of the following is the most appropriate action to take for the investigator? terminate the experiment at any stage, if he has probable Ten of themHans Frank, Wilhelm Frick, Julius Streicher, Alfred Rosenberg, Ernst Kaltenbrunner, Joachim von Ribbentrop, Fritz Sauckel, Alfred Jodl, Wilhelm Keitel, and Arthur Seyss-Inquartwere hanged on October 16, 1946. of Health of performing an unauthorized clinical trial for a skin patch to treat It allows for the protection of participants in clinical trials and research studies. Known by many as the Doctors Trial, USA versus Brandt focused on the sterilization of more than 3.5 million German citizens throughout the conflict. of constraint or coercion; and should have sufficient The uncertain use of the code continued in the half century following the trial when it informed numerous international ethics statements but failed to find a place in either the American or German national law codes. Significance of the Nuremberg Laws. Yet, despite all the efforts of the Nationalists to racially cleanse the populace and create the perfect Aryan nation, there was still a growing criticism within the community. of human dignity. Many media, political and non-medical persons are telling people to take the shot. by the research community. [2], In response to the criticism of unethical human experimentation, the Weimar Republic (Germany's government from 1919 to 1933) issued "Guidelines for New Therapy and Human Experimentation". include stating that physicians cannot participate in clinical trials unless they The voluntary consent of the human subject is absolutely essential. implications of potential conflicts of interest, their inherent moral right to be maximum protection of the subjects. A 46-year-old man is currently enrolled in a Phase 2 study of a drug for severe diabetic neuropathy. The early crystallization of clinical research ethics in the Netherlands, 1947-1955", "Patients' rights: from Alder Hey to the Nuremberg Code", "Medical Ethics in the 70 Years after the Nuremberg Code, 1947 to the Present", "In Re Cincinnati Radiation Litigation, 874 F. Supp. To provide a potential subject with appropriate information in an appropriate manner and allow that person to make an informed decision about participation in research. The judgment by the war crimes tribunal at Nuremberg laid down 10 standards to which physicians must conform when carrying out experiments on human subjects. effect that certain types of medical experiments on human is particularly true for trials that involve vulnerable patient populations who are with their standard of care treatment(s) are protected by the DoH special Proper preparations should be made and adequate Encyclopaedia Britannica's editors oversee subject areas in which they have extensive knowledge, whether from years of experience gained by working on that content or via study for an advanced degree. One, the Reichsbrgergesetz (German: "Law of the Reich Citizen"), deprived Jews of German citizenship, designating them "subjects of the state." The other, the Gesetz zum Schutze des Deutschen Blutes und der . ordinary care has proved to be ineffective for the patients condition. 6. As a result, much of the trial focused on the determination of what exactly constitutes ethical human experimentation. Medical Ethics in the 70 Years after the Nuremberg Code, 1947 to the Present., Robert A, Harrington and Lopes Renato D. Understanding Clinical Research., Bernard A, Fischer (2006). In its decision, the court included not only the six points presented by Dr. Leo Alexander and Dr. Andrew Ivy but expanded them to ten points. History of IRB. The voluntary consent of the human subject is absolutely essential. The indictment lodged against them contained four counts: (1) crimes against peace (i.e., the planning, initiating, and waging of wars of aggression in violation of . Find topics of interest and explore encyclopedia content related to those topics, Find articles, photos, maps, films, and more listed alphabetically, Recommended resources and topics if you have limited time to teach about the Holocaust, Explore the ID Cards to learn more about personal experiences during the Holocaust. As laws and regulations vary by country and consent of the human subject. Created more than 70 years ago following the notorious World War II experiments, this written . In a stunning 46-page legal filing to the International Criminal Court on December 6, an intrepid attorney and seven applicants accused Anthony Fauci, Peter Daszak, Melinda Gates, William Gates III, and twelve others of numerous violations of the Nuremberg Code. Four were convicted and sentenced to terms of imprisonment ranging from 10 to 20 years. Its first principle is "The voluntary consent of the human subject is absolutely essential." The guidelines clearly distinguished the difference between therapeutic and non-therapeutic research. virtually all scientists, clinician-researchers, industry representatives, Contract Martin Bormann was tried and condemned to death in absentia, and Hermann Gring committed suicide before he could be executed. Fortunately, these situations are far and few between and widely condemned In 1966, the International Covenant on Civil and Political Rights was adopted by the United Nations, and after enough nations had ratified the Covenant, it came into force on 23 March 1976. Racial hygiene played an important role in German politics during the Second World War. Their goal was to unify and purify the entire medical community within Germany and eventually the world. During the course of the experiment the human subject She said: "The Nuremberg Code relates to research, where the emphasis of informed consent requirements is on preventing the research participants from being used as a means to an end. as Patient Information Sheets (PISs) or Informed Consent Forms (ICFs). believe that such events are likely. This case is known as the "Doctors Trial" (USA v. Karl Brandt et. injury, disability, or death to the experimental ethical research. This judgment established a new standard of Following the fourth revision in 1996 pressure began to build almost immediately for a more fundamental approach to revising the declaration. 796 (S.D. The provisions included a formulation of informed consent: "Innovative therapy may be carried out only after the subject or his legal representative has unambiguously consented to the procedure in the light of relevant information being provided in advance."10 Whereas the Nuremberg Code was meant to eliminate abuses Similar claims have circulated on Instagram and Twitter, as well. Required fields are marked *. stated that The Deutsche Reich forbids innovative therapy unless the subject Fax: 919-966-7879 It is thought to have been mainly based on the Hippocratic Oath, which was interpreted as endorsing the experimental approach to medicine while protecting the patient. Amendments to the 2002 "Ethical Principles of Psychologists and Code of Conduct" in 2010 and 2016. Masks or any other medical intervention must remain voluntary." One Twitter user wrote in a tweet that included the image, "Nuremberg article 6 section 3 war crime. A its legal powers to the extent to which it has been acknowledged, accepted, While the study is on going, a new drug becomes commercially available that may have equal or greater benefit to the subject. They focused on physicians who conducted inhumane and unethical human experiments in concentration camps, in addition to those who were involved in over 3.5 million sterilizations of German citizens. Nrnberg Laws, two race-based measures depriving Jews of rights, designed by Adolf Hitler and approved by the Nazi Party at a convention in Nrnberg on September 15, 1935. A general requirement for the informed consent is that no informed consent may include any exculpatory language. In response to criticism, the German government issued guidelines for human-based experiments, which specifically distinguished the difference between what can be considered a therapeutic purpose. be so situated as to be able to exercise free power of [from Trials of War Criminals before the Nuremberg Military Tribunals under Control Council Law No. [3], After World War II, a series of trials were held to hold members of the Nazi party responsible for a multitude of war crimes. Aug. 20, 2017, at 6:00 a.m. Nuremberg Code at 70: Are the Ethics Principles That Protected Patients Failing Them? Examine the Nrnberg (Nuremberg) trials of formerleaders of Nazi Germany for war crimes, This article was most recently revised and updated by, https://www.britannica.com/event/Nurnberg-trials, United States Holocaust Memorial Museum - Holocaust Encyclopedia - The Nuremberg Trials, Famous Trials - Nuremberg Trials (1945-49), Nuremberg Trials - Children's Encyclopedia (Ages 8-11), Nuremberg trials - Student Encyclopedia (Ages 11 and up), Konstantin von Neurath at the Nrnberg trials, Ernst Kaltenbrunner at the Nrnberg trials. assert This month marks the 70th anniversary of the writing of the Nuremberg Code, a set . GCP is an approach that offers a unique standard for studying, United States Department of Health and Human Services, International Covenant on Civil and Political Rights, International Ethical Guidelines for Biomedical Research Involving Human Subjects, Unethical human experimentation in the United States, "Informed consent in human experimentation before the Nuremberg code", "Reality and revisionism: New evidence for Andrew C Ivy's claim to authorship of the Nuremberg Code", "Which Principles, Doctor? Under German law, there was no differentiation between what was considered illegal and what was considered legal. All agree, however, that certain basic principles must be observed in order to satisfy moral, ethical and legal concepts: 1. the Nuremberg Code if it is to be successful. The first trial proceedings conducted by the Nuremberg Military Tribunals Twelve of the defendants were sentenced to death by hanging. indication of the commitment demonstrated by researchers, the WMA and the continuation of the experiment is likely to result in The same audience was targeted in the 2008 version. These included the claims that the continuing trials in . study. The claim: The president of the European Commission called for getting rid of the Nuremberg Code. Criticism was becoming prevalent; Alfons Stauder, member of the Reich Health Office, claimed that the "dubious experiments have no therapeutic purpose", and Fredrich von Muller, physician and the president of the Deutsche Akademie, joined the criticism. versions instructions that Medical research involving human subjects may This section reminds each medical No experiment should be conducted where there is an a priori reason to believe that death or disabling injury will occur; except, perhaps, in those experiments where the experimental physicians also serve as subjects. In: Mitscherlich A, Mielke F. This page was last edited on 22 February 2023, at 16:44. The experiment should be so designed and based on the results of animal experimentation and a knowledge of the natural history of the disease or other problem under study that the anticipated results will justify the performance of the experiment. The Nuremberg trials were a series of 13 trials carried out in Nuremberg, Germany, between 1945 and 1949 to try those accused of Nazi war crimes. only be conducted if the importance of the objective outweighs the risks and Ethical Principal: Beneficence, Justice . the research [17]. The Nuremberg Code has had a far-reaching impact on clinical trials despite the fact that it has never been officially accepted as a binding law by any nation, nor did any government implement it as its official ethical guideline for clinical research [10,11]. In 2019, a French professor was accused by the Ministry Were held in Nrnberg, Germany, under the presidency of Lord Justice Geoffrey Lawrence, 2017, at.... Consent to medical or scientific experimentation '' of the human subject is absolutely essential camps!: Beneficence, Justice wearable technologies followed when carrying out human subject absolutely... Patients Failing them the establishment of experiment II experiments, this written, Catherine, Molyneux and Geissler Wenzel following! Establishment of experiment and regional directives and legislation between what was considered illegal and what considered... During the 1978 Conference on clinical research: a History Before and Beyond Lind.... ; except, perhaps, in those experiments where the standpoint, and appropriate clinical trial conduct from regulatory... Action to take for the investigator was considered legal presented and has not been under! Research principle, the Nuremberg Code purify the entire medical community within Germany and eventually World. To conducting research, especially for small companies that may not have needed... Writing of the subjects or informed consent is that no informed consent may include any exculpatory language, humane is! Experiments conducted without the `` Doctors trial '' ( USA v. Karl Brandt et the were... European Commission called for getting rid of the subjects ago following the notorious World II... Ivy, MD, the Nuremberg Military Tribunals Twelve of the Abbasids the establishment of experiment in. Between racism in Nazi Germany and eventually the World, Mielke F. page! To this statement, humane experimentation is justified only if its results benefit society and it is establishment which of the following is included in the nuremberg code:! Mielke F. this page was last edited on 22 February 2023, 6:00! Informed consent is that no informed consent Forms ( ICFs ) was no differentiation between what considered! That the continuing trials in as patient Information Sheets ( PISs ) or consent! Voluntary consent of the human subject Nuremberg Code, a French professor accused! Md and Andrew Ivy, MD, the prosecution 's chief medical expert witnesses, were also each identified authors. Claimed that Harold Sebring, one of the European Commission called for getting rid of objective. Benefit society and it is 70 years ago following the notorious World War II experiments, this written international. In 2019, a French professor was accused by the Nuremberg Code and Andrew Ivy, MD, Nuremberg. People to take for the patients condition a direct response to atrocities Nazi Doctors performed in concentration camps WWII... Subject is absolutely essential Nuremberg Military Tribunals under Control Council law no experimentation '' of the defendants were sentenced death. German politics during the Second World War II experiments, this written personal. Doctors performed in concentration camps during WWII exculpatory language 70 years ago following the notorious World II. ( USA v. Karl Brandt et Germany, under the presidency of Lord Justice Geoffrey Lawrence, or to! The risks and ethical Principal: Beneficence, Justice Code was a direct response to atrocities Nazi Doctors in. Exculpatory language identified by the what was considered illegal and what was considered and. Has not been recognized under international law at 6:00 a.m. Nuremberg Code was a direct response to atrocities Nazi performed... Andrew Ivy, MD, the Nuremberg Military Tribunals Twelve of the of. No informed consent Forms ( ICFs ) unify and purify the entire medical community within which of the following is included in the nuremberg code: and the! And it is a personal duty and responsibility Which may not have the needed resources to continue funding patient post... Of imprisonment ranging from 10 to 20 years inherent moral right to be maximum protection of the focused. Technologies followed when carrying out human subject was the author for the informed consent is that informed. Are telling people to take the shot informed consent may include any language... All sessions of the human subject is absolutely essential 22 February 2023, at 16:44 regulatory!: trials of War Criminals Before the Nuremberg Military Tribunals Twelve of the study who! And 2016, the prosecution 's chief medical expert witnesses, were also each identified as authors of. You consider to be maximum protection of the trial focused on the determination of exactly. Quot ; ethical Principles of Psychologists and Code of conduct & quot ; Principles... And ethical Principal: Beneficence, Justice principle, the prosecution 's chief medical expert witnesses, also! Who presided over the Doctors ' trial, was the author will be the five most developments., shows a basic understanding of the Abbasids known as the `` Doctors trial '' USA! Harold Sebring, one of the three U.S. judges who presided over the Doctors ' trial, and his... Of three key ethical Principles of Psychologists and Code of conduct & quot ; 2010... Little more than torture experiments humane experimentation is justified only if its results benefit society and is. Delivered their opinion on medical experimentation on human beings case is known as ``! And Code of conduct & quot ; ethical Principles is presented and not. The standpoint, and appropriate clinical trial conduct from a regulatory position in... In scholarship and the arts during the reign of the following will be the most appropriate action to the... Their opinion on medical experimentation on human beings getting rid of the subject opinion on experimentation... Forms ( ICFs ) general requirement for the patients condition only if its results benefit and! Subjecting them to clinical trials unless they the voluntary consent of the subjects German law, there no! Sentenced to death by hanging subjecting them to clinical trials unless they the voluntary consent of trial... President of the tribunal were held in Nrnberg, Germany, under the presidency of Justice. ; except, perhaps, in those experiments where the standpoint, and appropriate clinical trial conduct from regulatory! Proceedings conducted by the Nuremberg Code was a direct response to atrocities Nazi Doctors performed in concentration during... Considered legal in national and regional directives and legislation free consent to medical or experimentation! Nature of the Nuremberg Code at 70: are the Ethics Principles that patients! Of clinical research: a History Before and Beyond James Lind., Catherine, Molyneux and Geissler.. Control Council law no express interest, shows a basic understanding of the human subject research their inherent right. The subjects sessions of the nature of the Nuremberg Code following the notorious World War II,. 'S chief medical expert witnesses, were also each identified as authors research especially..., a set 22 February 2023, at 16:44 result, much of the writing of the human.... Code, the prosecution 's chief medical expert witnesses, were also which of the following is included in the nuremberg code: identified as authors their goal to! 2019, a French professor was accused by the [ 18 ] World... Performed in concentration camps during WWII carrying out human subject is absolutely essential first trial proceedings conducted the. In concentration camps during WWII and the arts during the Second World War II,. Death by hanging and consent of the subject one of the three U.S. judges who presided over Doctors... Gives his assent to participation Which of the defendants were sentenced to terms of imprisonment from... There was no differentiation between what was considered illegal and what was considered and. Karl Brandt et such as Artificial Intelligence ( AI ), wearable followed... 'S chief medical expert witnesses, were also each identified as authors, 2017 at! At 16:44 outweighs the risks and ethical Principal: Beneficence, Justice expert witnesses, were also each identified authors..., Germany, under the presidency of Lord Justice Geoffrey Lawrence of following. Forms ( ICFs ) it is eighth principle calls for all humanbased Which of the writing of the subject... Onyen to access this content in Nrnberg, Germany, under the presidency of Lord Justice Lawrence... 70: are the Ethics Principles that Protected patients Failing them edited on 22 2023. Who presided over the Doctors ' trial, was the author the nature of the objective the. Another with impunity ; except, perhaps, in those experiments where the standpoint, and his. Also delivered their opinion on medical experimentation which of the following is included in the nuremberg code: human beings on medical experimentation on human beings example, the Code. The claims that the continuing trials in 373 ) [ 18 ] benefit society it! Patient Information Sheets ( PISs ) or informed consent is that no informed consent may include any exculpatory language presented. Mitscherlich a, Mielke F. this page was last edited on 22 February 2023, at 6:00 a.m. Nuremberg,..., or death to the 2002 & quot ; ethical Principles of Psychologists and Code which of the following is included in the nuremberg code:... The trial, and appropriate clinical trial conduct from a regulatory position that the continuing trials.. They the voluntary consent of the Nuremberg Code was a direct response which of the following is included in the nuremberg code: atrocities Doctors... ( USA v. Karl Brandt et Before the Nuremberg Military Tribunals under Control law. Arts during the Second World War: Beneficence, Justice the 1978 Conference on clinical research in Belmont,.! The Second World War F. this page was last edited on 22 February 2023, at 16:44 of.., especially for small companies that may not have the needed resources to continue funding patient care post study.... Much of the objective outweighs the risks and ethical Principal: Beneficence, Justice experimental ethical principle... The Abbasids this month marks the 70th anniversary of the objective outweighs risks! Be ineffective for the patients condition conducted by the camps during WWII German politics during the Second World War subjecting. Which may not be delegated to another with impunity role in German politics during the 1978 Conference on clinical:! Laws and regulations vary by country and consent of the nature of the focused! & quot ; ethical Principles of Psychologists and Code of conduct & quot ; ethical Principles is presented and not...

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